The eLUCidate™ Reporter Cell Lines offer the following features and benefits

• Highest number of cells per vial (3 x 10^6) - Cells are ready for use shortly after thawing
• Optimized Luciferase reporter gene - High sensitivity and dynamic range
• Stringent quality control - Each cell line is tested for performance and sterility

Genlantis now offers a large collection of pathway reporter stable cell lines, all using a highly active luciferase reporter system.

Signal transduction pathways are the bridges that connect the extracellular environment cues, for example the binding by a specific cell surface receptor of a hormone, to the ensuing cellular response. These signaling pathways are composed mainly of proteins that can interact, move to specific cellular locations, or be modified or degraded.

Understanding the function of proteins in normal versus abnormal cellular environments is an important key to drug discovery processes. Having a clear knowledge of how a protein regulates signaling and metabolic pathways is a first step in disease research.Malfunctioning protein and/or signaling pathways are therefore very important in understanding the mechanism of a particular pathology, and may lead to the proper investigation of the cause of a disease, especially for cancer, and can also lead to possible targeted solutions.

Genlantis is pleased to offer a substantial collection of high quality Luciferase expressing reporter cell lines.The eLUCidate Reporter Cell Lines have been constructed with an optimized and highly active luciferase reporter technology. The variety of cell lines and transcriptional activators that Genlantis offers allows scientist to study the behaviors of multiple pathways of interest by monitoring luciferase activity after exposure to drug candidates or other stimuli.The eLUCidate Reporter Cell Lines allow users to measure the potency and selectivity of compounds on key pathways, especially if used in a high throughput system.

Shipping/Storage: All eLUCidate cell lines are shipped on dry ice only, and storage recommended in liquid nitrogen only

Cat# - Cell line - Reporter Pathway - Qty 3-4 x10^6EL-NFKBRAW- eLUCidate RAW 264.7 - NF-kB
EL-IL8RAW - eLUCidate RAW 264.7 - IL-8EL-AP1293 - eLUCidate HEK 293 - AP-1
EL-MIP2293 - eLUCidate HEK 293 - MIP-2EL-MIP2RAW - eLUCidate RAW 264.7 - MIP-2
EL-TNFA293 - eLUCidate HEK 293 - TNF-aEL-TNFARAW - eLUCidate RAW 264.7 - TNF-a
EL-TNFB293 - eLUCidate HEK 293 - TNF-bEL-TNFBRAW - eLUCidate RAW 264.7 - TNF-b
EL-GATA3293 - eLUCidate HEK 293 - GATA3EL-NFAT293 - eLUCidate HEK 293 - NFAT
EL-NFATRAW - eLUCidate RAW 264.7 - NFATEL-STAT1293 - eLUCidate HEK 293 - STAT1
EL-STAT1RAW - eLUCidate RAW 264.7 - STAT1EL-STAT3293 - eLUCidate HEK 293 - STAT3
EL-INOSRAW - eLUCidate RAW 264.7 - INOSEL-IL63T3 - eLUCidate NIH-3T3 - IL-6
EL-NRF2MCF7 - eLUCidate MCF7 - Nrf2EL-HREHELA - eLUCidate HeLa - HRE
EL-LEF293 - eLUCidate HEK 293 - TCF/LEFEL-RIGI293T - eLUCidate HEK 293T - RIG-I
EL-MDA5293T - eLUCidate HEK 293T - MDA5EL-IFNB293 - eLUCidate HEK 293 - TLR3/IFNB
EL-ISRE293 - eLUCidate HEK 293 - TLR3/ISREEL-IL8HELA - eLUCidate HeLa - TLR4/IL-8
EL-NFKB293 - eLUCidate HEK 293 - NF-kBEL-P53HELA - eLUCidate HeLa - p53
EL-TLR2293 - eLUCidate HEK 293 - TLR2/NF-kBEL-TLR3293 - eLUCidate HEK 293 - TLR3/NF-kB
EL-TLR7293 - eLUCidate HEK 293 - TLR7/NF-kBEL-TLR8293 - eLUCidate HEK 293 - TLR8/NF-kB
EL-TLR9293 - eLUCidate HEK 293 - TLR9/NF-kBEL-SRE293 - eLUCidate HEK 293 - SRE
EL-SRFRE293 - eLUCidate HEK 293 - SRF-REEL-CRE293 - eLUCidate HEK 293 - CRE
Cat# - Cell line - Reporter Pathway - Qty 2-3 x10^6
EL-STAT5BAF3 - eLUCidate Ba/F3 - STAT5EL-SBE293 - eLUCidate HEK 293 - SBE
EL-MRE293 - eLUCidate HEK 293 - MREEL-ATF6HELA -eLUCidate HeLa - ATF6
EL-TLR5293 - eLUCidate HEK 293 - TLR5/NF-kBEL-STAT4293- eLUCidate HEK 293 - STAT4
EL-ISRERAW - eLUCidate RAW 264.7 - ISREEL-NFKBJUR - eLUCidate Jurkat - NF-kB
EL-ISRE293 - eLUCidate HEK 293 - ISREEL-FOXP3JUR - eLUCidate Jurkat - FOXP3

Manuals - Cat# - Cell line - Reporter Pathway - Qty 3-4 x10^6EL-NFKBRAW - eLUCidate RAW 264.7 - NF-kB
EL-IL8RAW - eLUCidate RAW 264.7 - IL-8EL-AP1293 - eLUCidate HEK 293 - AP-1
EL-MIP2293 - eLUCidate HEK 293 - MIP-2EL-MIP2RAW - eLUCidate RAW 264.7 - MIP-2
EL-TNFA293 - eLUCidate HEK 293 - TNF-aEL-TNFARAW - eLUCidate RAW 264.7 - TNF-a
EL-TNFB293 - eLUCidate HEK 293 - TNF-bEL-TNFBRAW - eLUCidate RAW 264.7 - TNF-b
EL-GATA3293 - eLUCidate HEK 293 - GATA3EL-NFAT293 - eLUCidate HEK 293 - NFAT
EL-NFATRAW - eLUCidate RAW 264.7 - NFATEL-STAT1HELA - eLUCidate HeLa - STAT1
EL-STAT1RAW - eLUCidate RAW 264.7 - STAT1EL-STAT3293 - eLUCidate HEK 293 - STAT3
EL-INOSRAW - eLUCidate RAW 264.7 - INOSEL-IL63T3 - eLUCidate NIH-3T3 - IL-6
EL-NRF2MCF7 - eLUCidate MCF7 - Nrf2EL-HREHELA - eLUCidate HeLa - HRE
EL-LEF293 - eLUCidate HEK 293 - TCF/LEFEL-RIGI293T - eLUCidate HEK 293T - RIG-I
EL-MDA5293T - eLUCidate HEK 293T - MDA5EL-IFNB293 - eLUCidate HEK 293 - TLR3/IFNB
EL-ISRE293 - eLUCidate HEK 293 - TLR3/ISREEL-IL8HELA - eLUCidate HeLa - TLR4/IL-8
EL-NFKB293 - eLUCidate HEK 293 - NF-kBEL-P53HELA - eLUCidate HeLa - p53
EL-TLR2293 - eLUCidate HEK 293 - TLR2/NF-kBEL-TLR3293 - eLUCidate HEK 293 - TLR3/NF-kB
EL-TLR7293 - eLUCidate HEK 293 - TLR7/NF-kBEL-TLR8293 - eLUCidate HEK 293 - TLR8/NF-kB
EL-TLR9293 - eLUCidate HEK 293 - TLR9/NF-kBEL-SRE293 - eLUCidate HEK 293 - SRE
EL-SRFRE293 - eLUCidate HEK 293 - SRF-REEL-CRE293 - eLUCidate HEK 293 - CRE
Manuals - Cat# - Cell line - Reporter Pathway - Qty 2-3 x10^6
EL-STAT5BAF3 - eLUCidate Ba/F3 - STAT5 EL-SBE293 - eLUCidate HEK 293 - SBE
EL-MRE293 - eLUCidate HEK 293 - MREEL-ATF6HELA -eLUCidate HeLa - ATF6
EL-TLR5293 - eLUCidate HEK 293 - TLR5/NF-kBEL-STAT4293- eLUCidate HEK 293 - STAT4
EL-ISRERAW - eLUCidate RAW 264.7 - ISRE EL-NFKBJUR - eLUCidate Jurkat - NF-kB
EL-ISRE293 - eLUCidate HEK 293 - ISREEL-FOXP3JUR - eLUCidate Jurkat - FOXP3